Malignant pheochromocytoma with negative biochemical markers: Is it time to reclassify pheochromocytomas?

Malignant pheochromocytoma with negative biochemical markers: Is it time to reclassify pheochromocytomas?

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Pheochromocytomas are catecholamine producing tumors of adrenal gland generally diagnosed by presence of these markers in urine or plasma.However, a few may mickey mouse beach umbrella be marker-negative and challenging for clinicians.Several reports of these marker-negative pheochromocytomas may warrant necessity for a new classification of these tumors.Adrenergic blockade before surgery is one of the main reasons for recognition of these cases.We present a case of marker-negative pheochromocytoma which turned out to be malignant on its recurrence.

To our knowledge, this is the only case of 3 gallon flat back bucket malignant marker-negative pheochromocytoma reported in literature so far.Keywords: Pheochromocytoma, Adrenal, Catecholamines, Hypertension.